心功能不全被认为是众多心血管疾病的最终归宿。神经内分泌及代谢紊乱及调控异常在心血管疾病发生发展中的作用近年来倍受关注。瘦素(1epti m)作为肥胖基因的表达产物,由脂肪细胞分泌,是一种重要的机体能量平衡的调节因子,参与机体能量代谢。近年来,越来越多的学者研究发现,瘦素与心血管疾病有着密切的联系[1,2]。心钠素是慢 Cardiac insufficiency is considered the ultimate fate of many cardiovascular diseases. Neuroendocrine and metabolic disorders and regulatory abnormalities in the occurrence and development of cardiovascular disease in recent years has drawn much attention. As an expression product of obesity gene, leptin is secreted by adipocytes and is an important regulator of energy balance and participates in body energy metabolism. In recent years, more and more scholars have found that leptin and cardiovascular disease are closely linked [1,2]. Atrial natriuretic is slow