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目的探讨血尿酸(SUA)水平升高与T2DM患者动脉粥样硬化(AS)风险增高的相关性。方法选取T2DM患者248例,将SUA水平按照三分位法进行分组,采用B型超声检测各组颈动脉内-中膜厚度(CIMT)。结果 SUA水平与WC、BMI、FIns、TC、LDL-C、血肌酐(Scr)和CIMT呈正相关(P<0.01),与T2DM病程、FPG、HbA1c和肾小球滤过率(eGFR)呈负相关(P<0.01)。校正年龄、性别、T2DM病程、吸烟、饮酒、HbA1c、LDL-C、eGFR、HOMA-IR和BMI等因素后,高分位组CIMT发生颈AS风险高于低分位组[OR(95%CI):2.96(1.83~4.25),P=0.019]。结论 SUA水平是T2DM患者AS的独立危险因素。
Objective To investigate the relationship between the elevated serum uric acid (SUA) level and the risk of atherosclerosis (AS) in T2DM patients. Methods 248 patients with T2DM were selected. The SUA levels were grouped according to the tertile method. The carotid intima - media thickness (CIMT) of each group was measured by B - mode ultrasound. Results The level of SUA was positively correlated with WC, BMI, FIns, TC, LDL-C, Scr and CIMT (P <0.01) and was negative correlated with the duration of T2DM, FPG, HbA1c and glomerular filtration rate (eGFR) Related (P <0.01). After adjusting for age, gender, duration of T2DM, smoking, drinking, HbA1c, LDL-C, eGFR, HOMA-IR and BMI, the risk of cervical AS was higher in high- ): 2.96 (1.83 ~ 4.25), P = 0.019]. Conclusion SUA level is an independent risk factor for AS in T2DM patients.