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我院近期采用氮(艹卓)脒青霉素(Mecillinamum,上海第四制药厂生产)治疗46例经其它抗生素联合治疗无效的顽固性急性菌痢,收到满意的效果。治疗对象为1986年10月至1987年11月底临床确诊为急性细菌性痢疾、经联合抗菌治疗无效的住院患者,年龄自6个月至73岁,病程均在10天以上,最长达40天,平均13.7天。原使用抗菌药物情况如下:庆大霉素加吡哌酸或复方磺胺甲基异(口恶)唑18例,氨苄青霉素加吡哌酸6例,氨苄青霉素加庆大霉素8例,氨苄青霉素、庆大霉素加吡哌酸或利福平或复方磺胺甲基异(口恶)唑14例。临床均有发热、腹泻、脓血便、里急后重等症状。粪便镜检红、白细胞阳性率为100%。26例作粪便细菌培养,其中9例阳性,8例为福氏杆菌,1例为宋氏杆菌。
In our hospital recently, 46 cases of intractable acute bacillary dysentery treated with other antibiotics were treated with Mecillinamum (Shanghai No.4 Pharmaceutical Factory) and satisfactory results were obtained. The treatment of patients from October 1986 to the end of November 1987 clinically diagnosed as acute bacillary dysentery, the combined antibacterial therapy ineffective inpatients, ranging in age from 6 months to 73 years, duration of more than 10 days, up to 40 days , An average of 13.7 days. The original use of antibacterial drugs are as follows: gentamicin plus pipemidic acid or compound sulfamethoxazole (18 cases), ampicillin plus pipemidic acid in 6 cases, ampicillin plus gentamicin in 8 cases, ampicillin , Gentamicin plus pipemidic acid or rifampin or compound sulfamethoxazole (oxazole) in 14 cases. Clinical fever, diarrhea, pus and blood, tenesmus and other symptoms. Stool red microscopy, white blood cell positive rate of 100%. 26 cases of fecal bacterial culture, of which 9 were positive, 8 cases of Forsythia, 1 case of Song’s bacteria.