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目的探讨五酯胶囊对移植肾功能稳定的患者环孢素(CsA)全血浓度的影响及临床意义。方法回顾分析42例给予五酯胶囊提升环孢素浓度以达到降低服用剂量目的的肾移植患者的达治疗窗CsA服用剂量变化、移植肾功能、肝功能以及临床不良事件发生情况。结果42例患者服用五酯胶囊后6个月门诊检查数据与服用前比较:移植肾功能稳定[Cr(120.0±32.3)μmol/Lvs(132.1±38.2μmol/L)P>0.05]:达治疗窗CsA服用剂量减少2/3～1/2[(5.7±1.5)mg/(kg·d)vs(2.6±0.7)mg/(kg·d)P<0.05],不良反应、肝功能损害发生率均在较低水平。结论五酯胶囊能明显提高肾移植受者CSA全血浓度,减少CSA服用剂量,观察6个月移植肾功能无明显变化。
Objective To investigate the effect of Wuzhi Capsule on the concentration of CsA in patients with stable graft function and its clinical significance. Methods A retrospective analysis was conducted on the dose-adjusted CsA dosage, renal transplant function, liver function and clinical adverse events in 42 patients with renal transplant recipients who were treated with Wusheng capsule to increase the cyclosporine concentration in order to reduce the dosage. Results The data of outpatient examination at 6 months after taking pentobarbital capsule in 42 patients were compared with before treatment: the graft function was stable [Cr (120.0 ± 32.3) μmol / L vs (132.1 ± 38.2 μmol / L) P> 0.05] The dose of CsA decreased by 2/3 ~ 1/2 [(5.7 ± 1.5) mg / (kg · d) vs (2.6 ± 0.7) mg / (kg · d) Are at a lower level. Conclusion Wusi Capsule can significantly increase the whole blood concentration of CSA in renal transplant recipients and reduce the dose of CSA. No significant changes of renal function were observed after 6 months.