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支气管扩张药茶碱的血浆浓度超过治疗范围可引起致命的全身性惊厥发作。发生这种神经毒性表现的血药浓度的个体差异很大。这可能是因为一些病人存在茶碱致惊毒性的某些敏感因素,如肾衰就是这种危险因素。鉴于发热或环境引起的发热均可提高对惊厥的敏感性,本文用大鼠酵母致热模型,观察了发热对茶碱神经毒性的影响。动物为雄性Lewis大鼠,180±6g。实验前分笼单个喂养6天,室温23～25℃,12h光照与12h黑暗交替进行。实验前2天,行颈静脉硅胶导管插管。实验前12h,颈背部皮下注射15%Brewer′s酵母10ml/kg,以产生发热,对照组注射生理盐水。用直肠温度计测量深部体温。注射酵母可升高体温1.2±0.4℃。
Bronchodilator theophylline plasma concentrations exceed the therapeutic range can cause fatal systemic seizures. Individuals who experience this neurotoxicity vary widely in their plasma concentrations. This may be due to the fact that some patients have some of the theophylline-induced sensitivities, such as renal failure, a risk factor. In view of fever or environmental fever can increase the sensitivity to convulsions, this paper rat model of fever caused by fever observed on the theophylline neurotoxicity. Animals were male Lewis rats, 180 ± 6 g. Before the experiment, the animals were fed individually for 6 days, at room temperature of 23-25 ℃, 12h light and 12h darkness alternately. 2 days before the experiment, the line of cervical venous catheter catheterization. Twelveh before the experiment, 15% Brewer’s yeast 10 ml / kg was subcutaneously injected into the back of the neck to generate fever and the control group was injected with saline. Deep rectal temperature was measured using a rectal thermometer. Injection of yeast can increase body temperature 1.2 ± 0.4 ℃.