采用环糊精和油制备新型自组装载药系统——小珠受到越来越多的关注。小珠是一种球状颗粒,具有脂质囊腔结构,在制备过程中不需使用任何表面活性剂或有机溶剂。小珠囊腔内的脂质部分可溶解水难溶性药物和脂溶性药物,载药量大、能提高口服生物利用度,是很有发展潜力的口服新剂型。本文综述了小珠的制备原理、处方工艺和体内外性质等方面的研究进展,为其进一步应用提供基础。 The use of cyclodextrins and oils to prepare new self-assembled drug delivery systems - beads are receiving more and more attention. Beads are spherical particles with a lipid cyst structure that does not require the use of any surfactant or organic solvent during the preparation. Small lipid capsule cavity soluble in water-soluble drugs and fat-soluble drugs, drug loading, can improve oral bioavailability, is a promising new oral dosage forms. This review summarizes the research progress of the preparation principle, prescription technology, in vitro and in vivo properties of beads, and provides a basis for its further application.