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对于带瘤小鼠腹水、病人血清及肿瘤细胞培养上清液中的诸多生物因子,已有较多研究。作者用中性红摄取法就S_180腹水上清(AS)对M_4吞噬活性的抑制作用和对不同来源的肿瘤细胞(共9种)的生长刺激作用进行了较为详细的研究,发现在S_180小鼠腹水中存在有抑制M_4活性的因子.这种因子与正常小鼠或病毒免疫小鼠脾M_4在体外孵育时,能抑制M_4的吞噬活性。这种抑制作用随腹水上清剂量的增加、作用时间的延长而增强。
For the tumor-bearing mouse ascites, patient serum, and many biological factors in tumor cell culture supernatants, there have been many studies. The authors conducted a detailed study on the inhibitory effect of S_180 ascites fluid (AS) on the phagocytic activity of M_4 and the stimulation of the growth of tumor cells from different sources (a total of 9 species) using neutral red uptake method. The results were found in S_180 mice. There is a factor that inhibits M_4 activity in ascites. This factor can inhibit the phagocytic activity of M_4 when incubated with splenic M_4 of normal mouse or virus immunized mice. This inhibitory effect increases with the increase of the clear dose on the ascites and the prolonged action time.