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心房颤动(简称房颤)持续状态下肺静脉及其前庭可发生解剖学、组织学及电生理学特征的一系列改变:肺静脉及其前庭扩张;心肌细胞变性、间质胶原增生;管网系统及线粒体的异常;膜离子通道的表达异常;心肌有效不应期缩短并呈各向异性。这些改变可称为电-形态学重构,可能与心房后负荷增加、自主神经功能紊乱,心肌细胞能量代谢异常及钙超载等有关。这些变化又反过来为房颤的触发和维持创造条件,从而产生相互促进的病理过程。
A series of changes in the anatomy, histology and electrophysiology of the pulmonary veins and their vestibules under continuous atrial fibrillation (atrial fibrillation): dilatation of the pulmonary veins and their vestibules; cardiomyocyte degeneration, interstitial collagen hyperplasia; and vascular network and mitochondria Abnormalities of membrane ion channels; abnormal effective myocardial refractory period and anisotropy. These changes can be called electrical - morphological remodeling, may be related to increased atrial load, autonomic dysfunction, myocardial dysfunction of energy metabolism and calcium overload and so on. These changes in turn create the conditions for the triggering and maintenance of atrial fibrillation, resulting in a mutually reinforcing pathological process.