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本文研究目的在于判定β阻带剂是否有利于提高对全心缺血的耐受力,方法是观察普萘洛尔是否推迟缺血性心肌挛缩的发生和β阻滞在缺血心肌代谢中的主要作用.材料和方法:34条健康杂种犬(20～31kg)被随机分成对照组和普萘洛尔治疗组.治疗组在术前用普萘洛尔80mg,bid,共用4天.用戍巴比妥麻醉(30mg/kg),插管和控制呼吸,监测体表心电图和股动脉压,左侧开胸暴露心脏.治疗组动物术中在心脏切除前10分钟,静脉内加用普萘洛尔5mg/kg,而对照组则注射同等量的盐水,然后切下心肌使之造成完全缺血.每组中有5个心肌的左室腔内放置气囊,以测定缺血性心肌挛缩的开始发生时间和其发展.每组剩下的12个心脏,作左室游离壁穿刺,穿刺所得之心肌小片分成二半,一半作组织标本,另一半放入组织压缩性测定器用作研究.测定器通过间歇施加固定压力以测定心肌的可压缩性.每个心脏插入温度计,浸在恒温的水浴中,保持透壁心肌温度于37℃.用透壁组织作对照(大约心脏切除后3分钟),
The purpose of this study is to determine whether β blockers are beneficial to improve the tolerance to global ischemia by observing whether propranolol causes postponement of ischemic myocardial contracture and β blockade in ischemic myocardial metabolism The main role.Material and methods: 34 healthy mongrel dogs (20 ~ 31kg) were randomly divided into control group and propranolol treatment group.The treatment group preoperatively with propranolol 80mg, bid, shared 4 days with Shu Barbiturate anesthesia (30mg / kg), intubation and control of breathing, monitoring of surface ECG and femoral artery pressure, the left side of the heart exposed thoracotomy .In the treatment group animals in the heart before surgery 10 minutes, intravenous plus pulnan Lol 5mg / kg, while the control group was injected with the same amount of saline, and then cut the myocardium to cause complete ischemia .Each group of 5 myocardium placed in the left ventricular balloon, to determine the ischemic myocardial contracture Start time and development of each group of the remaining 12 of the heart, left ventricular free wall puncture, puncture the resulting small pieces of the heart into two halves, half for the tissue specimens, the other half into the tissue compressometer for research. The device determines the compressibility of the heart muscle by intermittently applying a fixed pressure Insert thermometer immersed in a thermostated water bath, maintained at a temperature of transmural myocardial 37 ℃. With transmural tissue as control (about 3 minutes after removal of the heart),