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目的 :探讨结直肠癌血管形成与其临床病理特征的关系。方法 :用免疫组化S P法 ,对 6 2例结直肠癌石蜡切片进行染色和微血管计数。结果 :伴淋巴结转移、远处转移及Duke’sB、C期结直肠癌组织中 ,微血管计数分别高于其相应无转移及Duke’sA期病人。结论 :结直肠癌肿瘤血管形成与其转移密切相关 ,微血管计数测定血管形成可作为预测结直肠癌转移潜能的标志。
Objective: To investigate the relationship between angiogenesis and clinicopathological features in colorectal cancer. Methods: Sixty paraffin sections of colorectal cancer were stained and microvascular counted by immunohistochemical SP method. Results: The microvessel counts in lymph node metastasis, distant metastasis and Dukes’sB and C colorectal cancer tissues were significantly higher than those in the corresponding non-metastasis and Duke’s patients. Conclusion: The angiogenesis of colorectal cancer is closely related to its metastasis. The determination of angiogenesis by microvascular count can be used as a marker to predict the metastatic potential of colorectal cancer.