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探讨反复癫痫发作对大鼠学习行为的影响及机制。方法采用光辨别学习和放免检测脑组织中生长抑素含量方法。结果随癫痫发作次数增多，大鼠光辨别学习能力明显减弱，达到学会标准所需时间明显延长（Ｐ＜０．０１），达标率明显降低。癫痫发作后，大鼠下丘脑、海马、颞叶皮层及额叶皮层组织中生长抑素含量明显增高（Ｐ＜０．０１），随癫痫发作次数增多，脑组织中生长抑素含量呈先上升后下降的现象（Ｐ＜０．０５～０．０１）。结论癫痫发作次数愈多，大鼠学习抑制效应愈明显，该效应可能与脑内生长抑素含量改变有关。
To investigate the effect and mechanism of recurrent seizures on learning behavior in rats. Methods Using light discrimination learning and radioimmunoassay to detect somatostatin content in brain tissue. Results With the increase of the number of seizures, the ability of light discrimination learning in rats was significantly weakened, the time required to reach the standard was significantly longer (P <0.01), and the compliance rate was significantly lower. After seizures, somatostatin levels in hypothalamus, hippocampus, temporal cortex and frontal cortex were significantly increased (P <0.01). With the increase of the number of seizures, the content of somatostatin in brain increased first After falling phenomenon (P <0.05 ~ 0.01). Conclusion The greater the number of epileptic seizures, the more obvious the effect of inhibition of learning in rats, the effect may be related to changes in brain somatostatin content.