论文部分内容阅读
目的观察辛伐他汀对冠心病患者的疗效与安全性。方法冠心病高脂血症患者87例随机分为两组-治疗组与对照组,治疗组分别服用辛伐他汀,对照组服用普伐他汀,观察血脂改变情况与不良反应发生情况。结果两组服药后均有明显调脂作用(P<0.05),其中治疗组调脂作用更强;两组不良反应发生情况相比无显著性差异。结论辛伐他汀治疗冠心病安全有效,临床上应用推荐使用大剂量。
Objective To observe the effect and safety of simvastatin on patients with coronary heart disease. Methods 87 patients with coronary heart disease and hyperlipidemia were randomly divided into two groups - treatment group and control group. Simvastatin was given to the treatment group and pravastatin was given to the control group. The changes of blood lipids and the incidence of adverse reactions were observed. Results Both groups had significant lipid-lowering effect (P <0.05), and the lipid-lowering effect was stronger in the treatment group. There was no significant difference between the two groups in adverse reactions. Conclusion Simvastatin is safe and effective in the treatment of coronary heart disease. High dose is recommended for clinical use.