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目的观察细胞增殖抗原Ki-67在基底细胞样乳腺癌(BLBC)中的表达,并分析其与基底细胞样乳腺癌临床病理特征的关系。方法将确诊的67例基底细胞样乳腺癌患者作为试验组,58例非基底细胞样型浸润性乳腺导管癌患者作为对照组,用链霉亲和素-生物素复合物免疫组化法(SABC法)检测Ki-67在2组患者乳腺组织中的表达。结果 Ki-67在对照组的表达阳性率为39.7%,在试验组的表达阳性率为94.0%,且在试验组的表达集中在中度或强阳性表达,组间差异有统计学意义(P<0.05)。Ki-67的表达与基底细胞样乳腺癌患者淋巴结转移及组织学分级有相关性(P<0.05),与年龄及肿瘤大小均无相关性(P>0.05)。结论 Ki-67可能参与基底细胞样乳腺癌的发生发展,提示其可作为判断基底细胞样型乳腺癌预后不良的免疫组化指标。
Objective To observe the expression of Ki-67 in basal-like breast cancer (BLBC) and to analyze its relationship with the clinicopathological features of basal-like breast cancer. Methods Sixty-seven patients with basal-like breast cancer were enrolled in this study. Fifty-eight patients with non-basal cell-like invasive ductal breast cancer as control group were treated with streptavidin-biotin complex immunohistochemistry (SABC Method) to detect the expression of Ki-67 in breast tissue of two groups. Results The positive expression rate of Ki-67 in the control group was 39.7%, the positive expression rate in the experimental group was 94.0%, and the expression in the experimental group was moderately or strongly positive (P <0.05). Ki-67 expression was correlated with lymph node metastasis and histological grade in patients with basal-like breast cancer (P <0.05), but not with age and tumor size (P> 0.05). Conclusion Ki-67 may be involved in the development of basal-like breast cancer, suggesting that Ki-67 may serve as an indicator of poor prognosis in basal-like breast cancer.