病人服用非甾体抗炎药(NSAIDs)常发生胃肠功能障碍,经内窥镜检查和测定便血,都证明NSAIDs可致明显胃肠粘膜损害,并可因上述胃肠不良症状的发生使治疗受到限制或被迫中断。一般认为NSAIDs导致胃肠粘膜损害的部分原因由于阻断了前列腺素类(PGs)合成,而PGs是维持粘膜完整性所必需。在用NSAIDs治疗前,动物或人预用前列腺素E,可明显减少NSAIDs引起的粘膜 Patients taking non-steroidal anti-inflammatory drugs (NSAIDs) often gastrointestinal dysfunction, endoscopy and determination of blood in the stool, have proved NSAIDs can cause significant gastrointestinal mucosal damage, and gastrointestinal symptoms can be caused by the above treatment Limited or forced to interrupt. Part of the reason that NSAIDs cause gastrointestinal mucosal damage is generally believed to be necessary for maintaining mucosal integrity due to blockage of the synthesis of prostaglandins (PGs). Prior to treatment with NSAIDs, animals or humans pre-use prostaglandin E, can significantly reduce the mucosa caused by NSAIDs