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目的观察高强度超声(HIU)作用于兔坐骨神经干后,其组织学变化及转归,为超声治疗临近大神经器官、组织提供与神经保护相关的实验依据,并为拓展超声在周围神经领域的应用提供实验基础。方法以不同的HIU剂量(强度×时间)作用兔坐骨神经干,然后观察作用处各时间点组织形态变化。结果作用0s(即对照组为假照)无明显组织学改变;作用15s(45.86W/cm2×15s)病变轻微,2周恢复;作用25s(45.86W/cm2×25s)病变加重,部分神经纤维轴突断裂、变性,3个月恢复;作用50s(45.86W/cm2×50s)大部分神经纤维凝固性坏死,6个月仍未恢复。结论坐骨神经受损伤程度与剂量大小有关,剂量小,损伤轻;剂量大,损伤重。在一定剂量范围内,受损神经可以完全恢复,剂量过大,受损神经难以恢复。
Objective To observe the histological changes and prognosis of hippocampus after high intensity ultrasound (HIU) treatment on the sciatic nerve trunk of rabbits. To provide experimental basis for the neuro-protection of the adjacent large nerve tissue by ultrasound and to explore the mechanism of ultrasound in the peripheral nerve Application provides experimental basis. Methods Rabbit sciatic nerve trunk was treated with different dose of HIU (intensity × time), and then observed the morphological changes at different time points. The results showed that there was no obvious histological change at 0s (control group was sham); the pathological changes were mild at 15s (45.86W / cm2 × 15s) and recovered at 2 weeks; the lesions at 25s (45.86W / cm2 × 25s) Axons rupture, degeneration, 3 months recovery; role 50s (45.86W / cm2 × 50s) most of the nerve fibers coagulation necrosis, 6 months has not yet recovered. Conclusion The degree of sciatic nerve injury is related to the dose size. The dosage is small and the damage is light. The dosage is large and the damage is heavy. In a certain dose range, the damaged nerve can be completely restored, the dose is too large, the damaged nerve is difficult to recover.