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目的:探讨围绝经期妇女情绪障碍的相关因素,为防治情绪障碍提供依据。方法:通过抑郁自评量表(SDS)和焦虑自评量表(SAS)来筛选病例,采用病例对照的研究方法,对病例组和对照组分别采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、生活事件量表(LES)、艾森克人格问卷(EPQ)、应付方式问卷测评,同时测量研究对象的激素水平,从多因素角度对围绝经期情绪障碍问题进行研究。结果:多因素分析结果显示,影响围绝经期情绪障碍的因素包括HAMD总分(OR=1.677)、HAMA总分(OR=1.581)、负性生活事件(OR=2.088)、神经质(OR=1.602)、自责(OR=1.859)为危险因素,而雌二醇(E2)(OR=0.632)、5-羟色胺(5-HT)(OR=0.598)为保护因素。结论:影响围绝经期妇女情绪障碍的危险因素较多,涵盖生理、心理、社会等诸多因素,除了传统的激素替代疗法外,还应重视通过心理、精神药物治疗。
Objective: To investigate the related factors of mood disorders in perimenopausal women and provide basis for prevention and treatment of emotional disorders. Methods: The cases were screened by Self-rating Depression Scale (SDS) and Self-rating Anxiety Scale (SAS). Case-control study was used to compare the case-control group and the Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Scale (HAMA), life event scale (LES), Eysenck Personality Questionnaire (EPQ) and coping style questionnaire were used to measure the hormones of the study subjects, and to study the problem of perimenopausal mood disorder from a multifactorial perspective. Results: Multivariate analysis showed that the factors influencing perimenopausal mood disorder included HAMD score (OR = 1.677), HAMA score (OR = 1.581), negative life events (OR = 2.088) and neuroticism ), And self-blame (OR = 1.859) as risk factors. Estradiol (OR = 0.632) and serotonin (5-HT) Conclusion: There are many risk factors affecting mood disorders in perimenopausal women, covering many factors such as physiology, psychology, society and so on. In addition to traditional hormone replacement therapy, psychotherapy and psychotropic drugs should be emphasized.