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直接以廉价的外消旋乳酸(D,L-LA)和赖氨酸(Lys)为原料,采用熔融聚合法合成药物缓释材料聚(乳酸-赖氨酸)共聚物[P(LA-co-Lys)]。用特性黏度[η]、FTIR1、H-NMR、GPC、DSC、XRD等手段对P(LA-co-Lys)进行了系统表征,探讨了催化剂种类和用量、熔融聚合反应时间、反应温度以及不同投料比对聚合物合成的影响。当单体乳酸和赖氨酸投料摩尔比为90/10,在160℃、70Pa、催化剂SnCl2的用量0.5%的条件下熔融聚合8h时,聚合物重均相对分子质量(Mw)可达6200。随着赖氨酸投料量的增加,共聚物Mw和玻璃化转变温度(Tg)逐渐降低,且共聚物均为无定形态,能满足药物缓释材料的要求。
Direct synthesis of drug-release material poly (lactic acid-lysine) copolymer [P (LA-co)] was synthesized by melt polymerization using cheap Lactated D, L-LA and Lys as raw materials. -Lys)]. P (LA-co-Lys) was systematically characterized by means of intrinsic viscosity [η], FTIR1, H-NMR, GPC, DSC and XRD. The effects of catalyst type and amount, polymerization time, reaction temperature, Effect of feed ratio on polymer synthesis. The weight average molecular weight (Mw) of the polymer reached 6200 when the molar ratio of Lactic acid to Lysine was 90/10, and was melt polymerized at 160 ℃, 70Pa and 0.5% SnCl2 for 8h. With the increase of lysine feeding amount, the Mw and glass transition temperature (Tg) of copolymers decrease gradually, and the copolymers are in an amorphous state, which can meet the requirements of drug sustained-release materials.