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食管癌的发病原因未完全明确.遗传与食管癌的关系已为人们所关注,尽管尚未取得一致性意见,但存在明显的家族集聚现象.我们发现1例高发家族,为外祖系,3代20人中9例患食管癌,报告如下:1 病例介绍(癌性家族谱附图)先证者(Ⅲ_3 ),男,36岁.进行性吞咽困难4个月,于1997年2月12日入院.术前X线检查和食管镜检均诊断为胸中段食管癌,于1997年2月18日行食管癌根治、胃代食管术.病理诊断:角化性鳞状细胞癌,食管旁淋巴结9/12转移,痊愈出院.追溯其家族3代20例成员,其母(Ⅱ_2)65岁,食管镜取活检证实为鳞状细胞癌,拒绝手术死亡.其父(Ⅱ_1)62岁死于食管癌,经手术病理证实为未分化癌,其姨母(Ⅱ_3)66岁,X线检查临床诊断为晚期食管癌,拒绝手术,死亡.其外祖母(I_3)73岁,X线检查临床诊断为食管癌,拒绝手术,死亡.先证者的同胞5人中,有4人患食管癌,均经病理证实为鳞状
The cause of esophageal cancer is not completely clear. The relationship between heredity and esophageal cancer has been of concern. Although no consensus has yet been reached, there is a clear family clustering phenomenon. We have found 1 case of a high-family, exo-family, 3 generations. Nine of 20 patients suffered from esophageal cancer, the report is as follows: 1 case presentation (cancerous family tree map) proband (III_3), male, 36 years old. Dysphagia for 4 months, on February 12, 1997 Admission. Preoperative radiographs and esophageal microscopy were all diagnosed as middle-thoracic esophageal cancer. On February 18, 1997, esophageal cancer was cured and gastro-esophageal esophageal surgery was performed. Pathological diagnosis: keratinizing squamous cell carcinoma, paraesophageal lymph nodes. 9/12 metastasis, healed and discharged. 20 members of 3 families were traced back to his family. His mother (II_2) was 65 years old. His esophageal biopsy confirmed squamous cell carcinoma and refused operation death. Her father (II_1) died of esophagus at the age of 62. Carcinoma, pathologically confirmed as undifferentiated carcinoma, the mother (II_3) 66 years old, X-ray examination of clinical diagnosis of advanced esophageal cancer, refused surgery, death. Her grandmother (I_3) 73 years old, X-ray examination of clinical diagnosis of esophageal cancer , Rejection of surgery, death. Four of the five of the proband’s compatriots suffered from esophageal cancer, all confirmed by pathology as squamous