超极化激活环核苷酸门控通道(HCN)是目前基因治疗心律失常的研究热点。心脏生物起搏即利用生物学及其相关技术,修复或替代受损的自律性节律点和(或)特殊传导系统,使心脏的起搏和传导功能得以恢复。心脏生物起搏器应用于临床仍面临许多问题,但是随着分子生物学和基因工程技术的发展,心脏生物起搏器必将造福于人类。 Hyperpolarization-activated cyclic nucleotide gated channels (HCNs) are currently the hot topics for gene therapy of arrhythmias. Cardiac biological pacing is the use of biology and its related technologies to repair or replace impaired, self-regulating rhythm points and / or special conduction systems to restore cardiac pacing and conduction. Cardiac biological pacemaker is still facing many problems in clinical application, but with the development of molecular biology and genetic engineering technology, cardiac biological pacemaker will benefit human beings.