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酸性鞘磷脂酶(acid sphingomyelinase,aSMase)是鞘酯类代谢中一种重要的酶。关于aSMase在肿瘤中作用的研究还较少,但已发表的研究提示其与肿瘤的发生和发展有一定的关系。本文对aSMase的激活机制、在肿瘤生长中的作用及其应用价值进行了综述。
Acid sphingomyelinase (aSMase) is an important enzyme in sphingolipid metabolism. There is less research on the role of aSMase in cancer, but published studies suggest that it has some relationship with the occurrence and development of tumors. This article reviewed the mechanism of aSMase activation and its role in tumor growth and its application value.