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新入侵的童虫与成虫的抗原性是不同的,因此,寻求期特异性抗原作为针对最脆弱的幼虫期的免疫攻击手段,可视为抗血吸虫的部分战略目标。最近几年,经过大量体外实验,认为童虫可能是免疫干扰最适宜的靶子,新转变的童虫对抗体和中性粒细胞、嗜酸粒细胞、巨噬细胞、血小板以及利补体的细胞毒作用敏感。这些体外效应机制仅使极幼小的童虫易被杀死,而对感染5天后的肺期童虫常不起作用,在体外或体内,虫龄为24～28小时的虫体对细胞毒机制几乎不起反应。对
The newly invasive sperm and adult worms have different antigenicities, and therefore, the search for stage-specific antigens as a means of immunization against the most vulnerable larval stages can be considered as part of the strategic goal of anti-schistosomiasis. In recent years, after a large number of in vitro experiments, it is considered that the squirrels may be the most suitable target for immune interference. The newly transformed squirrels’ antibodies and the cytotoxic activities of antibodies to neutrophils, eosinophils, macrophages, platelets, and complement Sensitive. These in vitro mechanisms of action only allow very young juvenile insects to be easily killed, but often have no effect on lung stage juveniles after 5 days of infection. In vitro or in vivo, worms aged 24-28 hours are cytotoxic Almost unrelenting. Correct