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热中子的生物学效应和~(10)B-硼化物对其增强作用是中子俘获疗法的基本原理。~(10)B与热中子碰撞发生~(10)B(n,α)~7Li反应所产生的α和~7Li粒子是高LET射线,其LET分别为177keV/μm和409keV/-μm。由于增加了这些粒子的作用,~(10)B才使热中子的生物学效应增强。这些粒子的射程合计约为15μm,为了产生增强效果,必须有尽可能多的~(10)B原子分布在距DNA分子约15μm的范围内。以前曾试合成了几种~(10)B化合物,但尚未广泛应用于临床。
The biological effects of thermal neutrons and the enhancement of ~(10)B-borides are the basic principles of neutron capture therapy. The α and ~7Li particles produced by ~(10)B collision with thermal neutrons ~(10)B(n,α)~7Li are high LET rays with LET of 177 keV/μm and 409 keV/-μm, respectively. Due to the increased effect of these particles, ~(10)B enhances the biological effects of thermal neutrons. The range of these particles is about 15 μm in total, and in order to produce an enhancement effect, as many as 10 B atoms must be distributed within about 15 μm from the DNA molecule. Several ~(10)B compounds have been previously synthesized but have not been widely used clinically.