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近年来随着恶性疟原虫对氯喹抗药的发现和扩散,全球掀起了研究新抗疟药的高潮,出现了一批新药如国外研制的喹(口派)、氯苄硝喹、甲氟喹、卤泛曲林等,国内研制的双喹(口派)、咯萘啶、硝喹、青蒿素、蒿甲醚和青蒿酯钠等。我国抗疟新药的研制工作已达到了国际先进水平。一、国内目前抗疟新药的研究 (一)青蒿素及其衍生物青蒿素是从黄花蒿的干燥茎叶中提取出的抗疟成分,为半倍萜内酯,是抗疟药化学结构中的一个新类型。主要作用于疟原虫无性体,口服后吸收快,0.5～1小时血中
In recent years, with the discovery and spread of chloroquine resistance by Plasmodium falciparum, the climax of new antimalarial drugs has been set off in the world. A series of new drugs such as Quinocetone (Oral), Chlorpheniramine, Mecuronium , Halofurtrine and other domestic double Qu (mouth faction), pyronaridine, quinoline, artemisinin, artemether and artesunate sodium and so on. The development of new anti-malarial drugs in China has reached the international advanced level. First, the current domestic new anti-malarial research (A) artemisinin and its derivatives Artemisinin is extracted from the dried stems and leaves of Artemisia annua anti-malaria ingredients, for the semi-terpene lactone, anti-malarial chemical A new type in the structure. The main role of malaria parasites asexual, fast absorption after oral administration, 0.5 to 1 hour of blood