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为了研究病毒性肝炎患者人巨细胞病毒 (HCMV)重叠感染状况及其意义 ,本文采用核酸斑点杂交法检测了 130例急性和慢性病毒性肝炎患者外周血中HCMV -DNA ,并检测了患者的外周血T细胞亚群及血浆游离氨基酸谱。结果表明 :慢性肝炎组HCMV -DNA阳性率 (6 5 8% )显著高于急性肝炎组 (38 9% ) ,差异非常显著 (P <0 0 1) ;慢性肝炎中HCMV -DNA阳性组患者的CD3、CD4 亚群显著低于阴性组 (P <0 0 5) ;急性和慢性肝炎患者中HCMV -DNA阳性组的支链氨基酸 .芳香族氨基酸比值均显著低于HCMV -DNA阴性组。由此可见 :慢性病毒性肝炎患者因免疫力下降而易于发生HCMV -重叠感染 ,而HCMV -感染会进一步使患者的免疫功能受损 ,同时还会影响患者的氨基酸代谢功能 ,使肝炎病变迁延难愈。
In order to study the status and significance of HCMV infection in patients with viral hepatitis, the HCMV-DNA in peripheral blood of 130 patients with acute and chronic viral hepatitis was detected by dot blot hybridization and the peripheral blood of patients T cell subsets and plasma free amino acid profile. The results showed that the positive rate of HCMV-DNA in chronic hepatitis group (65.8%) was significantly higher than that in acute hepatitis group (38.9%) (P <0.01), and the positive rate of HCMV-DNA in chronic hepatitis group CD3 and CD4 subpopulations were significantly lower than those in the negative group (P <0.05). The ratios of branched chain amino acids to aromatic amino acids in HCMV-DNA positive group were significantly lower than those in HCMV-DNA negative group in acute and chronic hepatitis patients. Thus, patients with chronic viral hepatitis are susceptible to HCMV-over-infection due to decreased immunity, whereas HCMV-infection further impairs immune function in patients and also affects patients’ amino acid metabolism and prolongs the progression of hepatitis .