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目的:探讨早期干预对出生窒息的高危新生儿体液免疫、生长激素(GH)和胰岛素样生长因子1(IGF-1)的影响及临床评估价值。方法:对本院病房出生的105例窒息高危新生儿进行分组研究,按监护人是否接受后期干预治疗的意愿,将70例足月窒息新生儿分为干预组A1(40例)和对照组A2(30例),35例早产窒息儿分为干预组B1(20例)和对照组B1(15例),于出生后1d、3个月、6个月,检测IgG、IgA、IgM、GH和IGF-1含量。结果:窒息高危新生儿出生后体液免疫物质、GH和IGF-1水平两组间差异无统计学意义(P>0.05)。干预治疗3个月、6个月后,干预组体液免疫物质、GH和IGF-1均高于非干预组,差异均有统计学意义(P<0.05)。结论:对出生窒息高危新生儿进行早期干预可以提升其体液免疫、GH和IGF-1的水平,有利于提高窒息高危儿的生存质量。
Objective: To investigate the effect of early intervention on humoral immunity, growth hormone (GH) and insulin-like growth factor 1 (IGF-1) in high-risk neonates with asphyxia and its clinical value. Methods: A total of 105 newborns with high risk of asphyxia were enrolled in this study. According to the guardian’s willingness to accept late intervention, 70 neonates with full-term asphyxia were divided into intervention group A1 (n = 40) and control group A2 (N = 30). 35 preterm infants with asphyxia were divided into intervention group B1 (n = 20) and control group B1 (n = 15). IgG, IgA, IgM, GH and IGF were detected at 1, 3 and 6 months after birth -1 content. Results: There was no significant difference in the level of GH and IGF-1 between the two groups (P> 0.05). After intervention for 3 months and 6 months, the humoral immune substances, GH and IGF-1 in the intervention group were significantly higher than those in the non-intervention group (P <0.05). Conclusion: Early intervention in high-risk neonates with asphyxia can improve the humoral immunity, GH and IGF-1 levels and improve the quality of life in high-risk asphyxia children.