论文部分内容阅读
近年来,在肥胖的分子遗传学研究中人们陆续发现了与肥胖有关的基因ob,db,fa,fat和tub。肥胖蛋白则为肥胖基因编码的蛋白质,它是激素样代谢因子,具有调节食欲、能量消耗及体内脂肪贮存等生物学效应。人和动物的肥胖蛋白具有高度同源性及组织分布的特异性,其基因表达受营养等环境因子及多种生理因子的调控。肥胖蛋白的生物学效应与其在体内的正常转运及下丘脑中的受体、神经肽Y、黑皮素、刺蛋白等神经调节因子有密切关系。
In recent years, obesity-related genes ob, db, fa, fat and tub have been found in obese molecular genetics. Obese proteins are proteins encoded by obese genes. They are hormone-like metabolic factors that have the biological effects of regulating appetite, energy expenditure, and body fat storage. Human and animal obesity proteins have high homology and tissue distribution specificity, and their gene expression is regulated by nutrients and other environmental factors and a variety of physiological factors. The biological effects of obesity protein and its normal in vivo transport and hypothalamic receptors, neuropeptide Y, melanocortin, thorn protein and other neuromodulation factors are closely related.