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目的:探讨不同ABO血型患者下肢闭合骨折后下肢深静脉血栓形成（DVT）发生率的差异。方法:回顾性研究2014年8月至2018年6月西安交通大学医学院附属红会医院创伤骨科收治的1 951例下肢骨折患者，男924例，女1 027例；年龄中位数为63（46, 78）岁（16~102岁）。按照血型分组：O型组572例，A型组564例，B型组609例，AB型组206例。入院12 h内常规行双侧下肢深静脉超声检查。比较所有下肢骨折患者、膝关节以近骨折患者、膝关节周围骨折患者、膝关节以远骨折患者，以及< 60岁骨折患者、≥60岁骨折患者不同血型组的DVT发生率。结果:O型组、A型组、B型组、AB型组下肢骨折患者DVT发生率分别为26.75%(153/572)、28.72%(162/564)、34.32%(209/609)、29.61%(61/206)，其中B型组DVT发生率显著高于O型组，差异有统计学意义（n P<0.008）。膝关节以近骨折患者按ABO血型分组后DVT发生率分别为28.74%（98/341）、28.99%(100/345)、39.45%(144/365)、30.97%(35/113)，其中B型组DVT发生率显著高于O型组和A型组，差异均有统计学意义（n P< 0.008）。在膝关节周围骨折患者、膝关节以远骨折患者及0.05）。年龄≥60岁患者按ABO血型分组后DVT发生率分别为30.99%（97/313）、33.33%(108/324)、45.22%(156/345)、34.74%(33/95)，其中B型组DVT发生率显著高于O型组和A型组，差异均有统计学意义（n P<0.008）。n 结论:不同ABO血型下肢骨折后DVT的发生率不同，B型血DVT发生率最高。血型对于下肢骨折后DVT发生率的影响主要表现在膝关节以近骨折和60岁以上的患者。“,”Objective:To investigate the differences in incidence of deep vein thrombosis (DVT) after closed fracture of lower extremity between patients with different blood types ABO.Methods:A retrospective study was conducted in the 1, 951 patients who had been admitted to Department of Orthopaedics Trauma, Honghui Hospital Affiliated to Xi'an Jiaotong University for lower extremity fractures from August 2014 to June 2018. They were 924 males and 1,027 females with a mean age of 63 (46, 78) years (range, from 16 to 102 years). Of them, 572 were type O, 564 type A, 609 type B and 206 type AB. Venous ultrasonography was performed on both lower extremities within 12 hours after admission. The incidences of DVT after fracture were compared between different blood types in all the patients, patients with proximal fracture of the knee, peri-knee fracture and distal fracture of the knee, and patients<60 years old and ≥60 years old.Results:The incidences of DVT were, respectively, 26.75% (153/572), 28.72% (162/564), 34.32% (209/609) and 29.61% (61/206) for patients with blood type O, type A, type B and type AB. The DVT incidence for type B was significantly higher than that for type O (n P< 0.008). The incidences of DVT were, respectively, 28.74% (98/341), 28.99% (100/345), 39.45% (144/365) and 30.97% (35/113) for blood type O, type A, type B and type AB in the patients with proximal fracture of the knee. The DVT incidence for blood type B was significantly higher than those for blood type O and blood type A (n P< 0.008). There were no significant differences in the DVT incidence between different blood types ABO in the patients with peri-knee fracture, distal fracture of the knee,0.05). The incidences of DVT were, respectively, 30.99% (97/313), 33.33% (108/324), 45.22% (156/345), 34.74% (33/95) for blood type O, type A, type B and type AB in the patients ≥60 years old. The DVT incidence for blood type B was significantly higher than those for blood type O and blood type A (n P< 0.008).n Conclusions:The incidence of DVT varied with different blood types ABO after lower extremity fracture. The highest DVT incidence was found in patients with blood type B. The impact of blood type on the DVT incidence after lower extremity fracture was mainly observed in the patients with proximal fracture of the knee or an age of ≥ 60 years old.