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目的 探讨丙型肝炎病毒(HCV)经性传播的可能性和HCV感染的危险因素。方法 采用EIA-Ⅱ检测抗-HCV阳性者及其配偶、性病门诊就医者、暗娟及嫖客、HIV/AIDS患者的血清抗-HCV,并用逆转录巢式聚合酶链反应(RT-PCR)法检测上述血标本的HCV RNA。另设抗-HCV及HCV RNA阴性的健康者及其配偶(20对)作为对照。结果 (1)84例HCV感染者及丙肝患者中HCVRNA阳性51例(60.78％),阴性33例(39.22％);其配偶有2例(2.38％)抗-HCV或HCV RNA阳性,她们的丈夫均为HCV RNA阳性的活动性肝硬化患者,33例HCV RNA阴性患者配偶中无HCV感染;(2)149例性病门诊就医者有2例抗-HCV和HCV RNA均阳性(1.34％);(3)40例暗娼和44例男性嫖客各有1例抗-HCV和HCV RNA阳性,均未用避孕套,而使用避孕套者中无HCV感染。(4)23例HIV/AIDS患者中有6例抗-HCV阳性(26.09％);(5)20对抗-HCV阴性者及其健康配偶(对照组)无HCV感染。结论 本研究表明HCV经性传播确实存在,但HCV感染者的配偶及一般性病患者中的感染率较低,可能和避孕套的使用与HCV感染者血中病毒载量较低有关;但HIV/AIDS患者中HCV感染率高达26.09％(6/23),表明HCV与HIV有共同的传播途径,后者可促进HCV感染的发生;丙肝患者HCV RNA阳性串与其ALT明显增加(正常值2倍以上)、肝病的严重程度等有关,患者肝病程?
Objective To investigate the possibility of sexual transmission of hepatitis C virus (HCV) and the risk factors of HCV infection. Methods Serum anti-HCV was detected by EIA-Ⅱ in anti-HCV positive and spouse, STD clinics, HIV / AIDS patients and clients, and RT-PCR The HCV RNA in the above blood sample is detected. Another set of anti-HCV and HCV RNA-negative healthy individuals and their spouses (20 pairs) as a control. Results (1) HCVRNA was positive in 84 cases (60.78%) and 33 cases (39.22%) in HCV-infected and HCV-infected patients, 2 cases (2.38%) were positive for HCV RNA or HCV RNA, None of the 33 HCV RNA negative patients had HCV infection in their spouses who were HCV RNA positive active cirrhotic patients. (2) Two of the 149 STD clinic patients were positive for anti-HCV and HCV RNA (1.34%); ( 3) There were 1 anti-HCV and HCV RNA positive for each of 40 female sex workers and 44 male sex workers. No condom was used, while those who used condoms had no HCV infection. (4) 6 out of 23 HIV / AIDS patients were positive for anti-HCV (26.09%). (5) There was no HCV infection in 20 anti-HCV negatives and their healthy spouses (control group). CONCLUSIONS: This study shows that HCV transfusions do occur, but the prevalence among spouses and patients with STDs in HCV-infected patients is low, and condom use may be associated with lower blood viral load in HCV-infected individuals. However, HIV / The HCV infection rate in AIDS patients was as high as 26.09% (6/23), indicating that HCV and HIV have a common route of transmission, which can promote the occurrence of HCV infection; hepatitis C patients with positive HCV RNA and its ALT significantly increased (more than 2 times normal ), The severity of liver disease, etc., the patient’s liver disease?