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目的:分析复方苦参注射液防治放化疗引起的口腔黏膜炎的有效性。方法:通过检索2000年1月—2015年1月期间中国知网(CNKI)、维普期刊数据库以及万方数据平台的文献;收集有关复方苦参注射液辅助放化疗与单纯放化疗相比较的随机对照试验(RCT),采用Rev Man 4.3版统计学软件进行Meta分析。结果:复方苦参注射液可以减轻严重的口腔黏膜炎[RR=0.33,95%CI(0.24,0.46)](P<0.01),减轻患者中、重度口腔疼痛[RR=0.21,95%CI(0.10,0.45)](P<0.01)。结论:复方苦参注射液可防治放化疗引起的口腔黏膜炎,减轻患者痛苦,但是纳入试验方法学的质量稍低,需要更高质量的随机对照临床试验进一步证实。
Objective: To analyze the effectiveness of compound Kushen injection in prevention and treatment of oral mucositis caused by radiotherapy and chemotherapy. Methods: By searching the literature of China National Knowledge Infrastructure (CNKI), VIP database and Wanfang data platform from January 2000 to January 2015, the randomized controlled trials were conducted to compare the efficacy and safety of the compound radix salviae miltiorrhizae radiotherapy with radiotherapy and chemotherapy alone Controlled Trials (RCTs) Meta-analysis was performed using Rev Man 4.3 statistical software. Results: Compound Kushen injection can relieve severe oral mucositis [RR = 0.33, 95% CI (0.24,0.46)] (P <0.01), relieve moderate and severe oral pain in patients [RR = 0.21,95% CI 0.10, 0.45)] (P <0.01). Conclusion: Compound Kushen injection can prevent and treat oral mucositis caused by radiotherapy and chemotherapy and relieve the patient’s pain. However, the quality of the included test methodology is slightly lower, which needs further confirmation by higher quality randomized controlled clinical trials.