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以人外周血淋巴细胞非程序ＤＮＡ合成（ＵＤＳ）为观察指标，研究了莪术和硫酸镍的遗传毒性效应及莪术对硫酸镍诱导的人外周血淋巴细胞ＵＤＳ的影响。结果表明，莪术对人外周血淋巴细胞ＵＤＳ无诱导效应，但当剂量达到１ｇ／ｍｌ时，可显著阻抑３Ｈ－ＴｄＲ向细胞ＤＮＡ的掺入。硫酸镍可大量诱发人外周血淋巴细胞ＵＤＳ，莪术对硫酸镍和紫外线诱导的人外周血淋巴细胞ＵＤＳ有明显抑制，且存在剂量效应关系。提示莪术在一定剂量时可明显减轻硫酸镍对人外周血淋巴细胞ＤＮＡ的损伤，而其本身无致突变作用。但当莪术剂量达到１ｇ／ｍｌ时，对ＤＮＡ的修复合成可造成抑制。
Using non-programmed DNA synthesis (UDS) of human peripheral blood lymphocytes as an observational indicator, the genotoxic effects of Curcuma zedoaria and Ni sulphate were studied, and the effect of Curcuma zedoaria on UDS of human peripheral blood lymphocytes induced by nickel sulfate was studied. The results showed that Curcuma had no effect on the UDS of human peripheral blood lymphocytes, but when the dosage reached 1 g/ml, it could significantly inhibit the incorporation of 3H-TdR into cell DNA. Nickel sulphate can induce human peripheral blood lymphocyte UDS in large numbers, and curcumin can significantly inhibit UDS of human peripheral blood lymphocytes induced by nickel sulfate and ultraviolet radiation, and there is a dose-effect relationship. It is suggested that Curcuma can significantly reduce the damage of nickel sulfate to DNA of human peripheral blood lymphocytes at a certain dose, but it has no mutagenic effect by itself. However, when the curcumin dose reaches 1 g/ml, the repair and synthesis of DNA can be inhibited.