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目的:分析阿托伐他汀对冠心病患者脂蛋白(a)、血清胆固醇酯转运蛋白(CETP)水平的影响及临床疗效。方法:将112例冠心病患者随机分为对照组与观察组,每组56例。对照组患者采用辛伐他汀治疗,观察组患者采用阿托伐他汀治疗。观察并比较两组患者治疗前后血清LP(a),CETP,超敏C-反应蛋白(hs-CRP)及脑钠肽(BNP)水平,冠状动脉血流储备、舒张期峰流速及收缩期峰流速变化,左心室后壁厚度(LVPWT)、左心室收缩末期内径(LVESD)及左心室舒张末期内径(LVEDD)情况,以及临床疗效。结果:治疗后,观察组LP(a),CETP,hs-CRP及BNP水平均低于对照组,差异有统计学意义(P<0.05);观察组冠状动脉血流储备、舒张期峰流速、收缩期峰流速均高于对照组,差异有统计学意义(P<0.05);观察组LVPWT、LVESD、LVEDD均低于对照组,差异有统计学意义(P<0.05);观察组总有效率高于对照组,差异有统计学意义(P<0.05);两组安全性比较,差异无统计学意义(P>0.05)。结论:阿托伐他汀对冠心病患者的临床疗效比较明确,可下调LP(a)及血清CETP表达。
Objective: To analyze the effect of atorvastatin on lipoprotein (a), serum cholesterol ester transfer protein (CETP) in patients with coronary heart disease and its clinical efficacy. Methods: 112 patients with coronary heart disease were randomly divided into control group and observation group, 56 cases in each group. Patients in the control group received simvastatin and patients in the observation group received atorvastatin. The levels of LP (a), CETP, hs-CRP and BNP, coronary blood flow reserve, diastolic peak velocity and systolic peak in both groups were observed and compared before and after treatment Flow velocity changes, left ventricular posterior wall thickness (LVPWT), left ventricular end-systolic diameter (LVESD) and left ventricular end-diastolic diameter (LVEDD), and clinical efficacy. Results After treatment, the levels of LP (a), CETP, hs-CRP and BNP in the observation group were significantly lower than those in the control group (P <0.05). The coronary flow reserve, diastolic peak flow velocity, (P <0.05). The LVPWT, LVESD and LVEDD of the observation group were lower than those of the control group (P <0.05). The total effective rate of the observation group was significantly lower than that of the control group Higher than the control group, the difference was statistically significant (P <0.05); two groups of safety comparison, the difference was not statistically significant (P> 0.05). Conclusion: Atorvastatin has definite clinical effect on patients with coronary heart disease, and can downregulate the expression of LP (a) and serum CETP.