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目的：探讨血栓抽吸联合替罗非班治疗急性ST段抬高心肌梗死（STEMI）患者冠状动脉内血栓病变的疗效。方法选择2011年11月至2014年11月山西省心血管病医院收治的STEMI冠状动脉血栓病变患者70例，将其随机分为对照组34例与观察组36例。对照组仅接受经皮冠状动脉介入治疗（PCI），观察组则采用血栓抽吸联合替罗非班治疗。比较两组治疗前后心功能及NT-proBNP水平、相关观察指标（无复流发生率、CTFC水平、心肌呈色3级血流、ST段下降>50%及CK-MB达峰时间）、MACE事件发生率。结果（1）两组治疗后LVEDD、LVESD及NT-proBNP水平均显著低于治疗前（P<0.05、P<0.01），两组治疗后LVEF水平均显著高于治疗前（P<0.05），且两组治疗后上述指标水平差异均具有统计学意义（P50%及CK-MB达峰时间差异均具有统计学意义（P<0.05）；（3）对照组MACE总发生率为29.41%，显著高于观察组（11.11%）（P50% and time to peak CK-MB),MACE event rate were compared.Results (1)The two groups after treatment LVEDD,LVESD and NT-proBNP levels were significantly lower than before treatment (P<0.05,P<0.01), after treatment,LVEF was significantly higher than before treatment (P<0.05),and the index level between the two groups were statistically significant (P 50% and CK-MB The peak time of the differences were statistically significant (P<0.05);(3) in the control group was 29.41% overall incidence of MACE was significantly higher than in the observation group (11.11%) (P<0.05). Conclusion Thrombectomy combined tirofiban acute ST-segment elevation myocardial infarction coronary thrombus significant efficacy,MACE low incidence, should be promoted in the clinical application.