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有些恶性肿瘤细胞表面存在高水平表皮生长因子受体(EGFR).EGFR的排列顺序与?-erb-B致癌基因产物颇为一致,因而它可能提示肿瘤更具有侵袭性.此研究旨在评价~(123)I-表皮生长因子(EGF)在宫颈鳞状细胞癌淋巴结转移灶内是否出现浓聚.选择14例Ⅲ～Ⅳ期宫颈癌患者,因为这类病人淋巴结转移可能性很大.经病人同意,于注射~(123)I-EGF前一天和后3天,口服高氯酸钠封闭甲状腺.采用Iodogen法标记~(123)I使成无菌无热源的EGF(ICI)标记物、比活性为370MBq/mg,每个脚蹼间皮下注射50μg.分别拍照双腿和腹部的前位和后位平面闪
Some malignant tumor cells have high levels of epidermal growth factor receptor (EGFR) on their surface. The order of EGFR alignment is quite consistent with the --erb-B oncogene product, so it may suggest that the tumor is more aggressive. This study aimed to evaluate ~ (123)I-epidermal growth factor (EGF) was found to be concentrated in lymph node metastases of squamous cell carcinoma of the cervix. Fourteen patients with stage III-IV cervical cancer were selected because of the high likelihood of lymph node metastasis in these patients. Agreed that on the day before and after the injection of ~(123)I-EGF for 3 days, oral sodium perchlorate was used to block the thyroid gland. The Iodogen method was used to label ~(123)I as a sterile pyrogen-free EGF (ICI) marker and ratio. The activity was 370MBq/mg, and 50μg was injected subcutaneously between the ankles. The anterior and posterior plane flashes of the legs and abdomen were photographed respectively.