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我院自1986年2月～1987年2月在住院病人中随机抽样27例慢性乙肝病毒(HBV)感染患者,给予人白细胞干扰素(IFN),作为治疗组,全部病例HBsAg、HBeAg阳性超过6个月;年龄18～43岁,平均31岁;男19例,女8例;病程11～69个月。全部病例经肝活检证实;CAH、CPH、CAH伴肝硬化倾向者和慢性HBV携带者分别为11、7、4、5例。以同期住院25例慢性HBV感染者给予安慰剂作为对照组。治疗方法治疗组:IFN(第二军医大学生产,500万u/5ml)500万u/d,肌注,每周3次,共8周。对照组:口服复方维生素B溶液,3次/d,每次10ml。两组患者在给予IFN或安慰剂前及后每周检测SGPT、SGOT及甲、乙肝血清学指标,并同时抽取血清标本放置在-20℃低温冰箱中12～24月,集中送检HBV、DNA、DNAP(ElisA法、)两组在停药后12～18个月分别有15和10例重复肝活
In our hospital from February 1986 to February 1987 inpatients randomly selected 27 cases of chronic hepatitis B virus (HBV) infection, given human leukocyte interferon (IFN), as a treatment group, all cases of HBsAg, HBeAg positive more than 6 Months; aged 18 to 43 years, mean 31 years; 19 males and 8 females; course of 11 to 69 months. All cases were confirmed by liver biopsy; CAH, CPH, CAH with cirrhosis and chronic HBV carriers were 11,7,4,5 cases. 25patients with chronic HBV infection in the same period were given placebo as control group. Treatment group: IFN (500 million u / 5ml produced by the Second Military Medical University) 5 million u / d, intramuscular injection, 3 times a week for 8 weeks. Control group: oral compound vitamin B solution, 3 times / d, each time 10ml. Two groups of patients before and after IFN or placebo were detected SGPT, SGOT and A, hepatitis B serological indicators, and at the same time the serum samples were placed in -20 ℃ low-temperature refrigerator 12 to 24 months, centralized submission of HBV DNA , DNAP (ElisA method) in the two groups after stopping 12 to 18 months were 15 and 10 cases of repeated liver live