慢性粒细胞性白血病 (chronicmyeloid leukemia,CML)是一种骨髓克隆性增生的多能干细胞异常的疾病 ,它伴有特异的细胞遗传的异常 ,即 Ph染色体阳性和 /或 bcl/abl 融合基因出现 [1 ]。其特点是慢性期病程 3a～ 5 a,然后是 3月～ 6月的加速期和急变期。慢性期一般无或有轻微症状 Chronic myeloid leukemia (CML) is a disease of bone marrow clonally proliferating pluripotent stem cells that is accompanied by specific cytogenetic abnormalities, ie, Ph chromosome positive and/or bcl/abl fusion gene [ 1 ]. It is characterized by a chronic phase of 3a to 5a, followed by an accelerated and blast crisis from March to June. There is generally no or mild symptoms in the chronic phase