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目的:对56例胃肠道间质瘤患者的临床病理特征和免疫组化特点进行分析。方法:对2010年1月~2013年12月于我院进行病理检查,且确诊为胃肠道间质瘤的56患者标本进行回顾分析,对胃肠道间质瘤的临床病理特征和免疫组化结果加以观察。结果:56例患者的肿瘤直径为1~13cm,且位于黏膜下层、肌间或浆膜下层,肿瘤切面界限均较清晰。肿瘤细胞主要包括两种,即梭形细胞和上皮样细胞。免疫组化分析,CD117阳性率为91.07%,CD34阳性率为76.79%,SMA阳性率为33.93%,S100阳性率为21.43%,Ki-67阳性率为37.50%。结论:对胃肠道间质瘤患者的病理诊断,需进行全面和深入的分析,CD117和CD34的阳性表达对该病的确诊,具有重要的临床意义,联合SMA、Ki-67和S-100,则能进一步提高确诊的准确率。
Objective: To analyze the clinicopathological features and immunohistochemical features of 56 patients with gastrointestinal stromal tumors. Methods: From January 2010 to December 2013 in our hospital for pathological examination, and diagnosed as gastrointestinal stromal tumors of 56 patients were retrospectively analyzed the clinical and pathological features of gastrointestinal stromal tumors and immune group The results of the observation. Results: The diameter of the tumors in 56 patients was 1 ~ 13cm, and located in the submucosa, intermuscular or subserietal, the tumor section boundaries are clear. Tumor cells mainly include two types, spindle cells and epithelial cells. Immunohistochemical analysis showed that the positive rate of CD117 was 91.07%, the positive rate of CD34 was 76.79%, the positive rate of SMA was 33.93%, the positive rate of S100 was 21.43% and the positive rate of Ki-67 was 37.50%. Conclusion: The pathological diagnosis of patients with gastrointestinal stromal tumors needs comprehensive and in-depth analysis. The positive expression of CD117 and CD34 has important clinical significance in diagnosing the disease. Combined with SMA, Ki-67 and S-100 , You can further improve the accuracy of the diagnosis.