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目的:观察与评价单纯用药与联合用药治疗外阴阴道假丝酵母菌病(VVC)的临床疗效。方法:根据Soble分类,将210例VVC患者随机分为两组,A组采用硝酸咪康唑阴道软胶囊1 200 mg治疗2个疗程(单纯用药组),B组采用硝酸咪康唑阴道软胶囊1 200 mg+伊曲康唑胶囊治疗2个疗程(联合用药组),于治疗后第7～14天和30天进行疗效评价。结果:210例患者中按要求复诊177例,临床有效率A组为87.7%,B组为94.8%,差异有统计学意义(P<0.05);真菌学转阴率A组为95.1%,B组为98.9%;用药依从性A组为77.9%,B组为90.6%,差异有统计学意义(P<0.05);30天复诊复发率A组为16.9%,B组为7.7%,P<0.05,差异有统计学意义。结论:单纯用药与联合用药均能有效治疗VVC;联合用药在临床有效率与依从性上优于单纯用药组;联合口服用药的复发率低于阴道单纯用药。
Objective: To observe and evaluate the clinical efficacy of simple and combined treatment of vulvovaginal candidiasis (VVC). Methods: According to the Soble classification, 210 patients with VVC were randomly divided into two groups. Group A was treated with miconazole nitrate vaginal soft capsule 1 200 mg for 2 cycles (pure drug group), while group B was treated with miconazole nitrate vaginal soft capsule 1 200 mg + itraconazole capsule for 2 courses (combination group), and evaluate the curative effect on days 7-14 and 30 after treatment. Results: Among the 210 patients, 177 cases were referred as required. The clinical effective rate in group A was 87.7%, in group B was 94.8%, the difference was statistically significant (P <0.05). The mycological negative rate in group A was 95.1%, B Group A was 77.9% in group A and group B was 90.6%, the difference was statistically significant (P <0.05) 0.05, the difference was statistically significant. Conclusions: Both simple and combined treatment can effectively treat VVC. Combination therapy is superior to simple therapy group in clinical efficiency and compliance. The recurrence rate of oral administration is lower than vaginal administration alone.