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目的:研究人参藏红花组合物预防急性高原反应的作用。方法:将昆明小鼠按照体重随机分为5组,分别为空白组、诺迪康0.56 g·kg-1组、人参藏红花组合物20,10,5 g·kg-1组。预先给予小鼠人参藏红花组合物7 d,末次给药后1 h观察其在常压缺氧环境下的存活时间,低压低氧后的游泳时间以及在低压低氧环境下的死亡率。结果:人参藏红花组合物20,10,5 g·kg-1均能延长常压缺氧小鼠的存活时间及低压低氧后小鼠的游泳时间,但对低压低氧环境下小鼠的死亡率无影响。结论:人参藏红花组合物能够提高小鼠的耐缺氧和抗疲劳能力,可用于预防急性高原反应。
Objective: To study the effect of ginseng saffron composition in preventing acute altitude sickness. Methods: Kunming mice were randomly divided into 5 groups according to body weight: blank group, nocturne 0.56 g · kg-1 group, ginseng saffron composition 20, 10, 5 g · kg-1 group. The ginseng safflower composition was pre-given for 7 days. The survival time under hypoxic hypoxia, the swimming time after hypobaric hypoxia and the mortality under hypoxia and hypoxia were observed 1 h after the last administration. Results: Ginseng safflower (20, 10, 5 g · kg-1) could prolong the survival time of hypoxic-hypoxic mice and the swimming time of hypoxic-hypoxic mice, but the death of mice Rate no effect. Conclusion: The ginseng saffron composition can improve hypoxia tolerance and fatigue resistance in mice and can be used to prevent acute altitude sickness.