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目的：探讨应用功能ＭＲＩ（ｆＭＲＩ）研究脑肿瘤患者手运动区（ＨＲＡ）的结构和功能变化特征。材料和方法：２２例位于或邻近初级运动皮质肿瘤患者采用单次激发ＧＲＥ－ＥＰＩ序列采集Ｔ＊２Ｗ图像，共３个周期即６个时相，每个周期包括手指对掌运动激发的１０幅活动图像和１０幅静止图像。经离线工作站重建获取减影后的差别图像，设定ＲＯＩ，描绘动态时间－信号强度曲线，测量信号强度（ＳＩ）上升百分率。结果：８例ＨＲＡ呈局限分布，１４例呈弥漫分布。肿瘤实体的边缘与ＨＲＡ活动中心的最短距离为０．３～２．８ｃｍ。有５例患者在肿瘤内见到高信号区。肿瘤侧ＳＩ上升百分率为１．５％～３％，正常侧ＳＩ上升百分率为２．５％～１０％。结论：对位于或邻近初级运动皮质脑肿瘤患者，功能ＭＲＩ为术前手术计划的制定提供了一种非侵袭性而有效的方法。如果肿瘤实体的边缘与ＨＲＡ活动中心的最短距离大于２．０ｃｍ者，术后手的运动功能一般不会受到损害。瘤与功能区的相互构筑关系，评估皮质中枢的功能状况，对外科手术具有指导价值。
Objective: To investigate the structural and functional changes of hand motion zone (HRA) in patients with brain tumor using functional magnetic resonance imaging (fMRI). MATERIALS AND METHODS: T * 2W images were collected from 22 patients with primary motor cortex tumors using single-shot GRE-EPI sequence for a total of 3 periods, ie, 6 phases. Each period included 10 finger-to-palm motion stimulated Moving images and 10 still images. An offline workstation was used to reconstruct the difference image after subtraction. The ROI was set and the dynamic time-signal intensity curve was plotted to measure the percentage increase of signal intensity (SI). Results: 8 cases of HRA showed localized distribution, 14 cases were diffusely distributed. The shortest distance between the edge of tumor and HRA activity center is 0.3 ~ 2.8cm. Five patients saw a high signal area within the tumor. The percentage of SI rise in the tumor side was 1.5% -3% and the percentage of SI rise in the normal side was 2.5% -10%. CONCLUSIONS: Functional MRI provides a non-invasive and effective method for the development of preoperative surgical planning for patients at or near primary motor cortex brain tumors. If the shortest distance between the edge of the tumor and HRA activity center is greater than 2.0cm, the motor function of the hand will not be impaired. Neoplasms and functional areas to build relationships with each other, to assess the functional status of the cortical center, has guiding value for surgery.