PProstate cancer (PCa) remains a prindpal cause of mortality in developed countries.Because no clinical interventions overcome resistance to androgen ablation therapy,management of castration resistance and metastatic disease remains largely untreatable.Metastasis is a multistep process in which tumor cells lose cell-cell contacts,egress from the primary tumor,intravasate,survive shear stress within the vasculature and extravasate into tissues to colonize ectopic sites.Tumor ceils reestablish migratorybehaviors employed during nonneoplastic processes such as embryonic development,leukocyte trafficking and wound healing.