维生素B12(Cyanocobalamin),简称VB12,又称氰钴氨素,是一类含有类似氰钴氨素维生素活性物质的总称。它是目前已经发现的最大、最复杂的维生素分子,也是唯一含有金属离子的水溶性维生素,是人体必需的维生素之一。1948年Rickes和Smith首次分别从肝脏中纯化和结晶维生素B12,1956年由Hodgkin等用X-射线法证明了其晶体结构:即中心咕啉环、中心环轴向Coβ配基部分及1个含有核苷酸环的Coα配基。咕 Vitamin B12 (Cyanocobalamin), referred to as VB12, also known as cyanocobalamin, is a class containing a similar cyanocobalamin vitamins active substance in general. It is the largest and most complex vitamin molecule that has been discovered so far. It is also the only water-soluble vitamin that contains metal ions and is one of the essential vitamins in the body. Rickes and Smith first purified and crystallized vitamin B12 from the liver in 1948, respectively, and X-ray method was used by Hodgkin et al. In5656 to confirm its crystal structure: centromere ring, axial central Coβ ligand part and 1 Co [alpha] ligand of a nucleotide loop. Goo