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目的探讨抗核抗体和抗心磷脂抗体对宫颈机能不全孕妇的临床意义。方法选择本院就诊并诊断为宫颈机能不全的患者147例作为观察组,健康孕产妇150例为对照组。比较2组孕妇ACA和ANA阳性率,宫颈机能不全患者中,将晚期流产史1次、2次~3次、>3次分别划分为A组、B组、C组,比较各组的ACA和ANA抗体阳性率。结果观察组ACA阳性率(34.69%)与对照组(8.67%)相比,差异有统计学意义;观察组ANA阳性率(31.29%)与对照组(7.33%)相比,差异有统计学意义;观察组ACA与ANA均阳性的比率(23.13%)与对照组(2.67%)相比,差异有统计学意义。观察组中A组、B组、C组的ACA阳性率分别为22.78%、35.00%、67.86%,两两差异比较均有统计学意义(P<0.05);A组、B组、C组的ANA阳性率分别为25.32%、32.50%、46.43%,两两比较差异均有统计学意义(P<0.05)。结论抗心磷脂抗体与抗核抗体水平检测对宫颈机能不全孕妇有重要辅助诊断、指导治疗的意义。
Objective To investigate the clinical significance of antinuclear antibodies and anticardiolipin antibodies in pregnant women with cervical incompetence. Methods Select 147 patients diagnosed as cervical incompetence in our hospital as observation group and 150 healthy pregnant women as control group. The ACA and ANA positive rate in two groups of pregnant women, patients with cervical incompetence, the history of late abortion 1, 2 to 3 times,> 3 times were divided into A group, B group, C group, comparing the ACA and ANA antibody positive rate. Results The positive rate of ACA in observation group (34.69%) was significantly higher than that in control group (8.67%). The positive rate of ANA in observation group (31.29%) was significantly higher than that in control group (7.33%) ; The positive ratio of ACA and ANA in observation group (23.13%) compared with control group (2.67%), the difference was statistically significant. The positive rates of ACA in group A, group B and group C were 22.78%, 35.00% and 67.86% respectively in the observation group, with significant differences between the two groups (P <0.05). The positive rates of ACA in group A, group B and group C The positive rates of ANA were 25.32%, 32.50% and 46.43% respectively, with significant differences (P <0.05). Conclusion Anticardiolipin antibodies and antinuclear antibodies detection of cervical dysfunction pregnant women have important auxiliary diagnosis, guiding the treatment of significance.