目的 :探讨L 精氨酸 (L arg)抗动脉粥样硬化 (AS)的作用机制。方法 :观察L arg对兔血管平滑肌细胞(VSMC)体外增殖的影响。结果 :L arg显著增加一氧化氮 (NO)含量 ,明显抑制VSMC ,并呈剂量依赖性。加入单甲基 L 精氨酸 (L NMMA) ,上述作用被逆转。结论 :L arg可显著抑制兔VSMC体外增殖 ,且此作用由L arg转化为NO而产生 ,L arg抗AS的作用可能与此有关 Objective: To investigate the mechanism of L arg against atherosclerosis (AS). Methods: The effect of L arg on the proliferation of vascular smooth muscle cells (VSMCs) in vitro was observed. Results: L arg significantly increased nitric oxide (NO) content, significantly inhibited VSMC in a dose-dependent manner. The effect was reversed by addition of monomethyl L-arginine (L NMMA). CONCLUSION: L arg can significantly inhibit the proliferation of rabbit VSMC in vitro and this effect is caused by the conversion of L arg to NO, and the effect of L arg anti-AS may be related to this