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背景:多发性抽动症的病因与发病机制尚未十分明了,至今还未发现有低铁血症与多发性抽动症发病关系的相关报道,在既往收治的多发性抽动症患儿中发现部分存在着低铁血症,辅以铁剂治疗后的症状改善较佳,为探讨多发性抽动症与血清铁之间的关系,特此设计该研究。目的:探讨小儿多发性抽动症与低铁血症之间的关系。单位:一所大学医学院护理学系,一所大学医学院附属医院儿科及一所区级医院儿科。对象:观察组45例为1997-06/2000-12汕头市澄海区人民医院儿科门诊收治的多发性抽动症患儿。均符合《中国精神疾病分类方案与诊断标准》第二版中关于多发性抽动症诊断标准,剔除符合上述表现但CT及MIR提示有脑器质性病变的患儿。方法:检测观察组45例多发性抽动症患儿的血清铁、血红蛋白及红细胞计数,并与对照组38例正常儿童进行比较分析。主要观察指标:两组之间血清铁水平的比较;两组之间低铁血症发生率的比较。结果:观察组的血清铁(12.79±0.67)μmol/L,低于对照组(19.26±5.38)μmol/L(P<0.005),低铁血症发生率为42%,高于对照组13%(P<0.005)。结论:多发性抽动症患儿有相当一部分存在低铁血症,低铁血症可能是多发性抽动症的发病因素之一。其机制可能是低铁血症引起了单胺氧化酶活力下降,导致单胺类神经递质异常。
BACKGROUND: The etiology and pathogenesis of Tourette’s disease are not yet clear. No reports have been found on the relationship between hyphemia and Tourette’s disease. Some of the previously reported children with Tourette’s syndrome Hematochezia, iron supplementation after treatment to improve the symptoms better, in order to explore the relationship between Tourette and serum iron, hereby hereby design the study. Objective: To explore the relationship between children with tic disorder and hyposmia. Unit: a Department of Nursing, University College of Medicine, a University Hospital Affiliated Hospital Pediatrics and a district hospital pediatrics. PARTICIPANTS: 45 cases of observation group were children with multiple tic disorder admitted to pediatric outpatient department of Chenghai People’s Hospital of Shantou City from June 1997 to December 2000. Are in line with the “China Mental Illness Program and Diagnostic Criteria” second edition of the diagnosis of multiple tic syndrome, excluding those who meet the above performance but CT and MIR prompted organic disease in children with brain lesions. Methods: Serum iron, hemoglobin and erythrocyte counts in 45 children with multiple tic disorder were observed in the observation group and compared with 38 normal children in the control group. MAIN OUTCOME MEASURES: A comparison of serum iron levels between the two groups; a comparison of the incidence of hypoferremia between the two groups. Results: Serum iron (12.79 ± 0.67) μmol / L in the observation group was significantly lower than that in the control group (19.26 ± 5.38 μmol / L, P <0.005). The incidence of hypothermia was 42% P <0.005). Conclusion: There is a considerable part of children with tic tinea sera have hypoferremia, hypoferremia may be one of the pathogenesis of Tourette’s disease. The mechanism may be caused by hypoferremia monoamine oxidase activity decreased, leading to monoamine neurotransmitter abnormalities.