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采用火箭电泳法、单向琼脂扩散法和放射免疫法,分别检测43例再障患者血液中AT-Ⅲ、α2-M、α1-AT及PC含量。结果表明,AT-Ⅲ、α2-M,PC抗原含量明显高于39例正常对照(P均<0.1),29例口服康力龙者AT-Ⅲ、α2-M,PC含量较14例未服康力龙者显著增高(P<0.01)。提示AT-Ⅲ、α2-M、PC含量增高可能是引起再障出血的原因之一。推测抗凝血蛋白增高与再障病人单核-巨噬细胞清除能力下降和应用蛋白同化类固醇激素有关。结果还显示,α1-AT含量随着出血程度加重而减低,故可作为再障出血的监视指标,并有利于动态观察病情。
The concentrations of AT-Ⅲ, α2-M, α1-AT and PC in blood of 43 patients with aplastic anemia were detected by rocket electrophoresis, one-way agar diffusion and radioimmunoassay respectively. The results showed that the content of AT-Ⅲ, α2-M and PC antigen was significantly higher than that of 39 normal controls (all P <0.1). The AT-Ⅲ, α2- Conor Long were significantly higher (P <0.01). Tip AT-Ⅲ, α2-M, PC content may be one of the causes of aplastic anemia. It is speculated that elevated anticoagulant protein and aplastic anemia in patients with monocyte - macrophage clearance decreased and the application of protein assimilation steroids. The results also showed that α1-AT content with the degree of bleeding aggravated and decreased, it can be used as a marker of aplastic anemia, and is conducive to dynamic observation of the disease.