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目前认为 mt DNAA15 5 5 G突变与氨基糖甙类抗生素致聋 (AAID)有关。通过调查采集了 6 6例 AAID病例 ,采外周血作 PCR- RFL P分析 ,对照组为 30例正常人 ,分析 mt DNAA15 5 5 G突变在 AAID中的作用。研究发现 :6 6例AAID患者中 ,14例具有 A15 5 5 G突变 ,而其余的 5 2例和对照组均无此突变。这表明 mt DNAA15 5 5 G突变是人体对氨基糖甙类抗生素遗传易感性的分子基础之一 ,基因和环境因素的相互作用可能在 AAID的发生中起重要作用。
It is currently thought that the mt DNAA15 55 G mutation is associated with aminoglycoside antibiotic-induced deafness (AAID). Sixty-six cases of AAID were collected from the survey. Peripheral blood was collected for PCR-RFLP analysis. The control group was 30 healthy subjects. The effect of mt DNAA15 55G mutation in AAID was analyzed. The study found: Of the 6 6 AAID patients, 14 had A15 55 G mutations, while the remaining 52 did not have this mutation. This indicates that the mt DNAA15 55 G mutation is one of the molecular basis of the genetic susceptibility of aminoglycoside antibiotics. The interaction between genes and environmental factors may play an important role in the occurrence of AAID.