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目的探讨IL-5、IL-12与哮喘的关系。方法大鼠48只,分为正常对照组和支气管哮喘组(模型组)。大鼠尾静脉取血分离血清,应用ELISA法,测量其血清IL-5、IL-12的水平。结果对照组的IL-5、IL-12的检测结果分别为(15·84±3·65)pg/ml,(79·32±6·48)pg/ml,模型组的分别为(39·15±13·13)pg/ml,(34·24±0·78)pg/ml。结论哮喘患者血清IL-5水平升高,IL-12水平下降。
Objective To investigate the relationship between IL-5, IL-12 and asthma. Methods Forty-eight rats were divided into normal control group and bronchial asthma group (model group). Serum from the tail vein of rats was used to separate the serum, and the serum levels of IL-5 and IL-12 were measured by ELISA. Results The results of IL-5 and IL-12 in the control group were (15.84 ± 3.65) pg / ml and (79.32 ± 6.48) pg / ml, respectively 15 ± 13 · 13) pg / ml, (34 · 24 ± 0.78) pg / ml. Conclusion Serum levels of IL-5 and IL-12 are decreased in asthmatic patients.