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目的探讨5型磷酸二酯酶在正常前列腺、良性前列腺增生组织中的表达及其临床意义。方法采用免疫组化技术检测正常前列腺组织及良性前列腺增生组织中的PDE5表达,并探讨PDE5表达与BPH患者的前列腺体积、PSA值、残余尿、年龄I、PSS、Qmax之间的关系。结果免疫组化结果显示:正常前列腺组织PDE5表达极弱,BPH中PDE5高表达。BPH组织中PDE5的表达与前列腺体积I、PSS、残余尿、PSA成正相关,但与年龄、最大尿流率无明显相关性。结论 PDE5在BPH组织中有较强表达,可能对BPH的病理生理过程产生重要作用。
Objective To investigate the expression of phosphodiesterase type 5 in normal prostate and benign prostatic hyperplasia (BPH) and its clinical significance. Methods The expression of PDE5 in normal prostatic tissue and benign prostatic hyperplasia was detected by immunohistochemistry. The relationship between PDE5 expression and prostate volume, PSA, residual urine, age I, PSS and Qmax in patients with BPH was analyzed. Results The results of immunohistochemistry showed that the expression of PDE5 in normal prostatic tissue was extremely weak and the expression of PDE5 was high in BPH. The expression of PDE5 in BPH was positively correlated with prostate volume I, PSS, residual urine and PSA, but no significant correlation with age and maximal uroflow rate. Conclusion PDE5 is highly expressed in BPH tissues and may play an important role in the pathophysiology of BPH.