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常山早在一千多年以前,我国即用为抗疟的主药。而四川中药研究所自黄常山(Dichroa-ebrifugaLor)叶中提出之常山碱(Feerifuqine)并制成常山碱二盐酸盐片(以下简称常山碱片),经药理试验证明其抗疟能力较奎宁为高,但由于其有恶心呕吐等副作用,未能应用在临床上。因而拟通过控制剂量和加镇吐剂等方法进行临床观察;以期找出常山碱既有效而又无呕吐副作用的适当剂量或寻出一种在临床上实用的防止常山碱致呕吐的有效药物。
More than 1,000 years ago, Changshan was used as the main antimalarial drug. The Sichuan Institute of Chinese Materia Medica originated from Feilifuqine in the leaves of Dichroa-ebrifuga Lor and made a nordanine dihydrochloride tablet (hereinafter referred to as Changshan soda tablet). The pharmacological test proved that its ability to resist malaria was higher than that of Kuikui. It is rather high, but because of its side effects such as nausea and vomiting, it cannot be used clinically. Therefore, clinical observations such as controlling doses and adding anti-emetic agents are planned; in order to find the appropriate dose of Changshan base that is effective without vomiting side effects or to find a clinically practical effective drug for preventing vomiting induced by tranexaine.