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异搏停(Verapamil,Iproveratril)原是一冠状动脉扩张剂,曾被用于治疗心绞痛,其后发现它还具有抗心律失常作用,对某些类型的心律失常具有显著的治疗效果。近年来,发现异搏停能选择性地阻断心肌细胞的Ca~(++)内流,这一发现在基础理论的探讨上有重大价值,激起了对异搏停的深入研究。本文仅就异搏停对心血管系统的药理作用、作用机理、适应症及应用时须注意的事项,作一简要介绍。对心血管系统的药理学作用异搏停对心血管系统的作用,主要表现为对血管平滑肌和心肌的直接抑制。血管无论是在整体动物或离体器官,
Verapamil (Iproveratril), formerly a coronary dilator, was used to treat angina pectoris and was later found to have anti-arrhythmic effects with significant therapeutic effects on certain types of arrhythmias. In recent years, it has been found that Verapamil can selectively block the Ca ~ (++) influx in cardiomyocytes. This finding is of great value in the discussion of basic theory and has stimulated further study of Verapamil. This article only on the cardiopulmonary bypass verapamil pharmacological effects, mechanism of action, indications and applications should pay attention to things, make a brief introduction. Pharmacological effects on the cardiovascular system Difceptance of cardiovascular effects on the system, the main manifestations of vascular smooth muscle and myocardial direct inhibition. Blood vessels either in the whole animal or isolated organ,